An accumulation of twisted and distorted neurofibrils found within neurons, especially as a feature of Alzheimer's disease and certain other neurological disorders.
Origin
1960s.
Definition of neurofibrillary tangle in US English:
neurofibrillary tangle
noun
An accumulation of twisted and distorted neurofibrils found within neurons, especially as a feature of Alzheimer's disease and certain other neurological disorders.